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Serious but Rare Side Effects Both medications carry warnings for more serious but uncommon side effects, occurring in less than 1-2% of patients: Pancreatitis (inflammation of the pancreas) Kidney problems Severe allergic reactions Thyroid tumors (seen in animal studies) Gastroparesis (delayed stomach emptying) Serious stomach issues Vision problems in some diabetics Retatrutides side effect profile appears similar to that of other incretin-based medications, though long-term safety data remains limited due to its investigational status

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The liver is the second-largest organ in the body with five major functions: filtration, digestion, metabolism and detoxification, protein synthesis, and storage of vitamins and minerals

Specific considerations for autoimmune disease patients: Delayed gastric emptying may affect absorption of oral medications, including some immunosuppressants Monitoring challenges in distinguishing disease activity from medication side effects Importance of maintaining stable immunosuppression regimens Patients should seek immediate medical attention for severe, persistent abdominal pain (potential pancreatitis or gallbladder disease), vision changes, severe vomiting/dehydration, neck mass/hoarseness, or allergic reactions

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