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The overall strategy is illustrated in Scheme 1

Current research on natural products continuously reveals new bioactive compounds that may manage developing health issues, rendering them essential in the ongoing search for innovative therapies [67,68,69,70]

By promoting the utilization of fatty acids for energy, L-Carnitine plays a crucial role in maintaining cellular energy homeostasis, supporting muscle function, and potentially aiding in the management of various metabolic disorders

doi: 10.1177/1545968310397706

Vitamin D supports endocrine function, promoting optimal reproductive health

If the phenotypes of the mutants can be successfully restored to wild type, this will confirm that only the correct genes have been deleted and further validate the specific phenotypes ascribed to each GDH mutant