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The defection of mitophagy will lead to the accumulation of dysfunctional mitochondria, resulting in the leakage of Cytc into the cytoplasm to induce the activation of the caspase signaling pathway, and contribute to cell death (Sinha et al., 2013

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Main limitation: selectivity figures (such as an in-vitro ~11.7-fold preference for senescent cells) come from cell models, not humans

In addition, TfR1 was the most abundant protein in these ligand affinity isolates

Citation: Adhikari, A., Aich, J., & Dhande, R

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