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Alternatively, the 1-helix of GLP-1R ECD is in close contact with the C-terminus of GLP-1

Balance of side-effects and benefits Because of the small numbers of patients affected by the eye condition in the study - who may not have been taking their medication as prescribed or be representative of the wider population - the statistics on risk may not be accurate

Hydration Many side effects, including headaches, dizziness, constipation, and fatigue, worsen with dehydration

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It can also occur with compounded semaglutide or compounded tirzepatide

This was confirmed in the recent AngioSafe study which showed no effect of GLP-1RA therapy on angiogenesis and no association between GLP-1 exposure and severe DRP was shown (129)