Semaglutide is administered via injection, which might cause some discomfort, similar to any other injection
Deficiency in B12 can lead to anemia, characterized by fatigue, weakness, and shortness of breath
When there are five right answers, the real question is no longer What is the best drug? The real question is Which drug for me? That question has historically been answered by clinical trial-and-error, start a patient on the conventional first-line option, see if it works, see if they tolerate it, switch if it does not, switch if they cannot
nejm.org/doi/full/10.10 Oral Semaglutide 25 mg delivers double-digit weight loss in OASIS-4 (Phase 3 trial) - - - Just out in @NEJM: A 71-week RCT tested oral semaglutide 25 mg daily in adults with overweight/obesity (no diabetes)
Ola M, Alhomida A
That suggests the amylin and GLP-1 pathways create a synergistic interaction, not just a combined one