Sleep deprivation increases ghrelin (the hunger hormone) and decreases leptin (the satiety hormone), essentially creating the opposite of what GLP-1 medications do
SUSTAIN-7 (N=1,201), a head-to-head trial against dulaglutide, reported mean weight loss of 5.5 to 7.3 kg at the 1 mg dose over 40 weeks, with A1C reductions of 1.8% from a baseline of approximately 8.2% 3
Retrieved from Pansari, A., Pan, X., Almond, L
This fullness can increase the likelihood of stomach contents, including acid, flowing back into the esophagus, especially if the lower esophageal sphincter (the muscle that acts as a valve between the stomach and esophagus) is weakened or relaxed
But its not surprising to see this kind of evolution where the US market pays more for something first and then [other international] markets start to pick it up, Sclafani added
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