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R 7 is C 1 -C 6 alkyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 2 -C 7 heterocycloalkyl, optionally substituted C 6 -C 10 aryl, C 3 -C 9 heteroaryl, optionally substituted C 1 -C 6 alkylC 6 -C m aryl, or optionally substituted C 1 -C 6 alkylC 3 -C 9 heteroaryl

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In addition, 0.1% MOS increased the intestinal thickness (50), and 4.5 mg raffinose increased the villus height to crypt depth ratio (51)

Retrieved from FDA: iData

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The Beers Criteria, a guideline for medication use in older adults, lists NSAIDs as potentially inappropriate due to high risk of GI bleeds and renal failure