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Collectively, by maintaining a reduced intracellular environment, GSH restrains pro-necrotic kinase activation and preserves inhibitory protease function, particularly CASP8, thereby preventing aberrant necroptotic signaling and inflammatory cell death

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Interestingly, changes in calcium homeostasis in the brain may contribute to the cognitive decline associated with normal aging and possibly to the development of neurodegenerative disorders (61, 62)

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