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Another Nrf2 activator is 4-octyl itaconate, an analogous of itaconate with immunoregulatory and antioxidative effects produced by decarboxylating cis-aconitate

In the chronic administration paradigm, animals received two different treatment regimens: a cycle of 4 to 6 injections of cisplatin at 3 mg/kg given over the course of 3 weeks (once every 4 days), followed by a 5-day recovery or a cycle of 2 injections of cisplatin at 5 mg/kg given at a 4 day interval, followed by a 5-day recovery

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With B-12 levels replenished, daily energy returns naturally