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A Mendelian randomization study from European cohorts confirmed a causal link between TGs, cholesterol levels, and depression phenotypes, indicating that these metabolic factors may bridge the connection between T2DM and depression, potentially mediating their association (256)

Liddington, R

243 This increases the levels of cytokines such as IL-1 and IL-6 and NLRP3 inflammasome activation in brain-resident cells

NAD+ is a coenzyme found in every cell, central to energy production and cellular repair and its levels decline with age

This polymorphism was retrospectively found to be over-represented in patients developing hepatotoxicity following intentional paracetamol overdose [39]

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