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Yet, the startling reality is that metabolic and nutritional factors, many of which are modifiable, are now recognized as primary drivers of its pathogenesis, contributing to a global burden that afflicts over 300 million people (1)

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Paul B, Lewinska M, Andersen JB

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[9] At pH values between about 2.5 and 4.1, [9] the carboxylic acid closer to the amine generally loses a proton, and the acid becomes the neutral zwitterion OOCCH(NH + 3 )(CH 2 ) 2 COOH

Despite high upfront costs, economic modeling suggests potential long-term value