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Indeed, the last three rows of Table 5 show that the up-regulation of CBS has exactly this effect and that the addition of oxidative stress makes the effect much stronger

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J Med Genet (2015) 52(9):63641

For instance, sudden changes in direction, excessive torsional forces, or high-impact activities can place significant strain on the ACL, potentially leading to injury

Notably, the adverse effects caused by metformin therapy for adolescent patients with PCOS, especially gastrointestinal side effects, need to be a concern, as they may affect their quality of life and treatment adherence