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Stable RAGE-heparan sulfate complexes are essential for signal transduction

Researchers study IGF1 LR3 to understand structure-activity relationships, how to optimize peptide half-life and uptake, and how to reduce unwanted binding to carrier proteins

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Gastrointestinal adverse effects, including nausea, vomiting, diarrhea, and constipation, are commonly reported, particularly during dose escalation phases

With a clear distinction between mechanistic plausibility, preclinical efficacy, and clinical support, narrative synthesis was arranged by phytochemical class and subsequently by translational relevance