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However, a significant decrease in insulinotropic activity was observed with GIP in diabetic patient with hyperglycemia, whereas relatively preserved activity was noted with GLP-1 in the same patients (58), suggesting divergent effects of GIP and GLP-1 on -cells ( Figure 1 Section B)

In preclinical models, selective glucagon receptor antagonism abolishes much of the weight loss benefit observed with triple agonism, confirming that the glucagon component is not redundant but mechanistically essential

Thats why we require a medical evaluation, history review, and ongoing monitoring before and during treatment.monitored program instead of scattered, separate interventions

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This once-weekly treatment supports metabolic balance as part of a structured 6-month care plan