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Animal studies, particularly in rodents, have shown that high-dose GLP-1 exposure can lead to pancreatic ductal proliferation and, in some cases, inflammatory changes

At the endometrial level, ROS and superoxide dismutase (SOD), an antioxidant enzyme, may have pertinent roles in triggering endometrial breakdown, with their levels varying during different phases of the endometrial cycle [20]

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extend to 16+ weeks for severe suppression