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As an inhibitor of NRF2, Keap1 recognizes and binds to the ETGE and DLG motifs of NRF2 via its Kelch repeat domain, thereby continuously suppressing and promoting the degradation of NRF2 [87]

N Engl J Med 377:839848 Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR et al (2019) Oral semaglutide and cardiovascular outcomes in patients with type 2 diabetes

This difference in half-life is one reason why the BPC-157 vs TB-500 research community often uses different dosing intervals for each compound when they are used independently

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