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Patients conditions were assessed at week 4, 8 and 12 after enrollment

All GLP-1 agonists carry a boxed warning regarding the risk of thyroid C-cell tumors based on rodent studies, though this risk has not been confirmed in humans

On arrival, male Wistar rats (Charles River, Margate, UK) or male C57BL6 mice (Harlan Laboratories) were housed in pairs and maintained at 2123 o C on a 12-h light, 12-h dark cycle (light period 07001900 h)

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In most, but not all cases we can achieve 1-2 shades of lightening with combination therapy

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