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Older adults, who often suffer from decreased hydrochloric acid in the stomach, and individuals with gastrointestinal (GI) disorders may have lower absorption of B12.2,4 Vitamin B12 deficiency may be characterized by megaloblastic anemia, fatigue, weakness, constipation, loss of appetite, soreness of the mouth or tongue, and weight loss
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Oral administration of propyl propane thiosulfonate restored the richness and evenness of gut microbiome lost due to dextran sodium sulfate-induced colitis in mice (Vezza et al., 2019)
FDAs new approach will likely undermine the incentive for those pushing peptides to study them in randomized trials and get them approved
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