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Plates were incubated for 48 h, at 37C and 150 rpm

The article explains that these medications slow and then accelerate the passage of food, and diarrhea follows when that overwhelms the colon's water-reabsorption capacity

Possible mechanisms of renal protection with SGLT2 inhibitors are multifactorial and it is likely that reduction in the glomerular capillary pressure, and reduction in an initial hyperfiltration, can contribute to the reduced albuminuria and prevention of renal impairment [62, 63]

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doi: 10.5694/mja2.50428 [PubMed] 34053705 Chiew AL, Buckley NA

The findings are published in Nature Medicine