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However, pharmacokinetic studies suggest that these comorbidities do not affect the pharmacokinetics of oral semaglutide, and based on the observed safety profiles, no dose adjustments are recommended [68, 69]

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The model-predicted pharmacokinetic parameters were well comparable with the observations, with the prediction errors (PE%) less than 17.73% for AUC, 20.63% for CL, and 37.76% for V ss across the animal species