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While the translational potential of Nrf2-targeted interventions is considerable, challenges remain, including risks of overactivation and oncogenicity, lack of reliable biomarkers, and barriers related to bloodbrain barrier permeability, dose, timing, and bioavailability

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[3] Other populations may experience effects at lower or higher dosages depending on differences in P-450 enzyme activity and other factors which affect the amount of NAPQI produced

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The secretions tend to be more fluid than that of the goblet cells, but the degree varies with the stimulus

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