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inhibited the MAPK signaling pathway via inhibition of ERK, JNK, and p38 phosphorylation, and inhibited the phosphorylation of IB- and NF-B

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A reduction in inhibition in the thalamus would therefore reduce inhibitory control of the thalamocortical relay cells, resulting in an increase in cortical excitability

LINE-1 elements, normally silenced by DNA methylation, show 36% reduced methylation, increasing transposable element activity and mutagenic potential (99)

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