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Endocrine 84:309319 [DOI] [PMC free article] [PubMed] [Google Scholar] 42.Nappi A, Miro C, Cicatiello AG, et al (2025) The thyroid hormone activating enzyme, DIO2, is a potential pan-cancer biomarker and immunotherapy target

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Across preclinical work, the most consistent signals are Remodeling of the extracellular matrix, including collagen and elastin pathways Anti inflammatory actions and modulation of oxidative stress markers Support for repair processes in tissue and skin models Human clinical data exist, but they are limited in size and quality

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