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The main causes of a vitamin B12 deficiency are as follows: Malabsorption due to poor intestinal health (inflammation, bacteria, fungal infection, parasites, disturbed intestinal flora) due to a lack of transport molecules (intrinsic factor), genetic diseases (cobalamin disease) or medications that hinder uptake

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Consumption of a high fat diet results in a surplus of NADH and FADH 2 that then increases the flux through the ETC with a resultant increase in ROS generation