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While some oral and sublingual formulations exist, injection remains the gold standard with the most research support

Simard, C

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However, the importance of correcting reductive stress is illustrated by the finding that in three Manchester patients with recurrent acute pancreatitis, who were referred after the trials, standard treatment failed: the addition of folate to provide more methyl groups did not help, but a choline supplement did (JM Braganza unpublished)

Sisley et al., 2014 )