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Targeting the Melanocortin System to Treat Hereditary Obesity While obesity most often arises from lifestyle choices, particularly surrounding the balance of caloric intake and physical activity 26, 27 , genetics may also play a role in a small subset of individuals

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Shortterm use appears generally well tolerated (possible injection discomfort, vivid dreams, transient sleep changes), but robust, longterm safety data in diverse human populations are still lacking

Exome sequencing supports a de novo mutational paradigm for schizophrenia