GIP Receptor Limb GIPR engagement is the distinguishing feature separating dual agonists such as tirzepatide from single GLP-1R agonists
Side effects may occur in the initial stage of supplementation as the body takes some time to adjust to the dose
doi: 10.1002/ana.20601 217 WasseffS
extreme tiredness (fatigue) shortness of breath chest pain or tightness problems with memory and concentration (brain fog) difficulty sleeping (insomnia) heart palpitations dizziness pins and needles joint pain depression and anxiety tinnitus, earaches feeling sick, diarrhoea, stomach aches, loss of appetite a high temperature, cough, headaches, sore throat, changes to sense of smell or taste rashes Ah
Median pain severity decreased by 25% in the active-treatment group (p=0.002), but did not change in the placebo group
They secrete growth factors that instruct follicular cells to proliferate and form hair