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One of the frequent epigenetic alterations in hepatocellular carcinoma (HCC) is hypermethylation of the promoters of the Secreted Frizzled-Related Protein (SFRP) gene family, which is a key component in the regulation of the Wnt/ -catenin signaling pathway

Long-term controlled safety data are absent

The second one [193] evaluated thyroid hormones and volume variations in 28 patients before and after 12 weeks of this dietary regimen: both fT3 and fT4 were significantly reduced, as well as thyroid volume, while TSH values were only slightly lower than before the AIP period

10.1007/s10654-020-00607-6 Eur J Epidemiol

Specific mechanisms proposed for this depressed level of vitamin D-metabolizing genes are hypermethylation of specific sites of genes and elevated BMI [37,38]

Acknowledgments The authors would like to thank Pat Kornic and the Pernicious Anaemia/B12 Deficiency Support Group and Tracey Witty and the B12 Info group ( Notes Funding There was no funding for this study