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In a statement released March 10, Novo Nordisk said it initially received inspectional observations from the FDA in February 2025, and that it has been working diligently to address those observations ever since. In the statement on Tuesday, the drugmaker acknowledged it received the warning letter and that it welcomes further dialogue with the US FDA. The company said it is working diligently to address the concerns of the FDA

Cureus 15 , e40379 (2023)

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During this process, partial electron transfer via NADPH-CYP450 reductase to the CYP450-substrate complex results in "electron leakage", leading to the incomplete reduction of O to O 2 or HO [129]

This result was further confirmed by western blot in U2OS cells, where NSD2 was undetectable upon treatment with 300 nM UNC12149 for 6 h (Supplementary Fig