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Patients with certain genetic profiles may experience peak appetite suppression at lower doses, while others benefit from faster dose escalation

doi: 10.1016/j.jalz.2013.12.007 2 LaneCAHardyJSchottJM

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Key mechanisms of action include: AMPK activation Berberine appears to activate adenosine monophosphate-activated protein kinase (AMPK), an enzyme that regulates cellular energy metabolism