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A polymorphism in the extracellular domain of the thyrotropin receptor is highly associated with autoimmune thyroid disease in females

Avoid strict calorie cutting

Rotate your injection sites with each dose to prevent lipohypertrophy (thickened fat deposits) that can develop from repeated punctures in the same spot

Don't wipe them dry

In light of the restriction on the importation of biotechnological APIs and given the lack of effective enforcement by ANVISA, which suffers from staffing shortages, it is foreseeable - and has already been observed - that clinics are directing their activities almost exclusively to tirzepatide and the situation is likely to worsen

Another option gaining attention is tirzepatide, which has shown even higher average weight loss in some trials (sometimes over 20% of body weight)