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Growth factors such as (e.g., VEGF, platelet-derived growth factor [PDGF] bind to a receptor tyrosine kinase (RTK) on the cell membrane, causing autophosphorylation of the receptor, thus creating docking sites for intracellular signaling proteins

According to postoperative computed tomography of the brain, as well as abdominal and pelvic organs, no metastatic lesions were detected

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