Apremilast (Otezla) is an oral anti-inflammatory drug that is approved by the Food and Drug Administration (FDA) for plaque psoriasis and psoriatic arthritis (FDA 2014
Writing calculations down creates a record for future reference and review
General Safety Profile Based on the preclinical dataset and the limited human exposure data: No prominent signal of hepatic, renal, or hematological toxicity at tested doses No prominent cardiovascular safety flag Pregnancy and lactation as with most research compounds, safety not established Long-term effects not characterized What Clinicians Should Actually Tell Patients For patients asking about 5-amino-1MQ, a reasonable response framework: What the compound is: A research-stage small molecule inhibiting NNMT with promising preclinical fat loss data
I could sleep without pain, move my shoulders with significantly less pain, and begin to regain my range of motion
I am SO Pleased with my results
Gut Microbiome Modulation in Diet-Induced Obesity (PubMed, 2022) 5-Amino-1MQ Establishes a Distinct Microbiome Profile in DIO Mice A study published on PubMed investigated the effects of 5-Amino-1MQ combined with a low-fat diet on the gut microbiome of diet-induced obese mice
