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Proteins such as tau, TDP-43, -synuclein, and polyglutamine-expanded proteins misfold and aggregate into toxic species that overwhelm the UPS and interfere with normal degradation processes

Poly(glutamic acid): from natto to drug delivery systems

Other Cause of B12 Side Effects Another thing to consider is what's in the B vitamins too

drug exposure (area under the curve and peak concentration) was similar in those with cirrhosis and healthy participants, with the 90% confidence intervals for the adjusted ratios spanning 1

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