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This finding is consistent with the speculation that p53 is widely regarded as undruggable. Surprisingly, several novel therapeutic approaches targeting p53, including MDM2/4 antagonists, compounds that target specific p53 mutants or restore the wild-type function of the mutated p53 protein, p53-based genetic therapies and p53-based tumor immunotherapy, have been developed in recent years

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10.1056/NEJMoa1206168 40 FormigliL.PaternostroF.TaniA.MirabellaC.Quattrini LiA.NosiD.et al (2015)

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