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doi: 10.3389/fphar.2020.00246 Received 02 October 2019 Accepted 24 February 2020 Published 17 March 2020 Volume 11 - 2020 Edited by Syed Nasir Abbas Bukhari, Al Jouf University, Saudi Arabia Reviewed by Miguel Prudncio, University of Lisbon, Portugal

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Its concentration decreases with age: from 200 ng/mL at age 20 to 80 ng/mL at age 60

Reconstituted with bacteriostatic water, 14 to 21 days refrigerated (28 days for most brand pens in use)

Investigation of the vitamin D receptor gene (VDR) and its interaction with protein tyrosine phosphatase, non-receptor type 2 gene (PTPN2) on risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY)