In TRIUMPH-4, participants with obesity and knee osteoarthritis taking retatrutide 12 mg lost ~28.7% of body weight (~71 lbs at 68 weeks) and saw substantial improvements in pain and function: WOMAC pain scores reduced by 4.5 points (75.8%) Meaningful gains in physical function, with many patients essentially free of knee pain by study end If these results are confirmed in broader use, were not just talking about weight loss drugs anymorewere talking about disease-modifying therapies that simultaneously target obesity, pain, mobility, and downstream CV risk
Regulating glucagon secretion: somatostatin in the spotlight
Highlights: Up to 28.7% weight loss in a 68-week late-stage trial Reduced knee osteoarthritis pain by up to 62.6% First triple-hormone injection targeting GLP-1, GIP, and glucagon Trusted Source Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial Go to source)
Pharmaceuticals (Basel) 2022, 15(6)
PlexusDx anticipates that compounding pharmacies will maintain competitive pricing as more patients discover this pathway
Our design strategy was based on achieving a unimolecular molecule that was equipotent to CagriSema in vitro on GLP-1R and AMYRs