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We estimate that people who are homozygous for the risk alleles at both the GLP1R and GIPR loci have a 14.8-fold increased odds (95% confidence interval [6.2, 35.8]) of tirzepatide-mediated vomiting, compared with those homozygous for the non-risk alleles
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Similar to scrapie, -synuclein pathology spreads in the peripheral and enteric nervous systems, then to CNS, whereas Alzheimers tau pathology propagates within the CNS only, beginning in the brainstem then involving cortical areas in a characteristic pattern (Braak and Del Tredici, 2016
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