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If you experience severe or persistent vomiting that prevents you from keeping fluids down, severe abdominal pain, or any symptoms that feel like more than standard GI distress, contact your healthcare provider or go to the emergency room

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After 72 weeks: Participants taking 5 mg of tirzepatide lost 15% of their starting body weight on average Those taking 10 mg lost an average of 19.5% Those taking the highest dose, 15 mg, lost an average of 20.9% Another phase 3 clinical trial studied the efficacy of once-daily orforglipron in people with obesity and found that it resulted in significant weight loss compared to placebo

It is taken as an injection once a week

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