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Clinical trials demonstrate that gradual dose escalation produces similar cumulative weight reduction compared to faster schedules, but with significantly fewer dropouts due to side effects

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Also, GSH status was measured in the fasting state only, defined by the protocol as at least a 12-hour, overnight fast, further reducing possible sources of variability

Study strengths and limitations Strengths of the study were that it included follow-up after 28 weeks off treatment, and the high rates of treatment adherence and trial completion

This was in comparison to the control group where both males and females showed increased body adiposity while body adiposity and weight of gonadal fat pads decreased in KIR and KID mice [3]

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