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In addition to ESCs, cardiac progenitor cells (CPCs) from diabetic patients have been shown to exhibit decrease enzymatic activity of not only G6PD, but also transketolase (TKT) another NRF2 target gene ( NRF2 has also been shown to play an important role in overseeing mitochondrial biogenesis and metabolism, although direct confirmation of target genes involved in these processes has been lacking (Piantadosi et al., 2008)

Senolytic therapy alleviates A-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimers disease model

Type 1 diabetes mellitus (T1D) Pathogenesis of diabetes has not been completely understood yet, but alterations in gut microbial composition have been described in both type 1 (T1D) and type 2 (T2D) diabetes, suggesting a potential role in the disease development [58]

The study also underscores the need for stronger international collaboration and clinical translation