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[73] showed that the effect of GLP-1 RAs (in particular of liraglutide) in reducing the levels of liver damage biomarkers is closely related to the body weight loss and better glycemic control

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For patients with chronic kidney disease (CKD) or clinical heart failure and atherosclerotic cardiovascular disease, an SGLT2 inhibitor with proven benefit should be considered GLP-1 receptor agonists are generally recommended as the first injectable medication, except in settings where type 1 diabetes is suspected Intensification of treatment beyond dual therapy to maintain glycaemic targets requires consideration of the impact of medication side-effects on comorbidities, as well as the burden of treatment and cost The panel say that the lack of evidence over specific combinations of glucose-lowering therapies remains an issue, and more research is needed