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[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Begaye B, Vinales KL, Hollstein T, Ando T, Walter M, Bogardus C, Krakoff J, Piaggi P

Those can be minimized, but not always eliminated, by starting with very low doses and gradually increasing over weeks to months

Second, controlled release treatment results in more efficient drug utilization and less of the compound remains as a residue

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