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Baseline health states were assigned based on having had a hospitalisation for MI, stroke or HF from 2010 to 2019, or having developed ESKD at any point before 2019

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People who have severe gastrointestinal conditions like inflammatory bowel disease (IBD) or gastroparesis should not go on GLP-1s, and neither should people with a personal or family history of multiple endocrine neoplasia 2A, multiple endocrine neoplasia 2B, medullary thyroid cancer, or pancreatitis

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The process of mixing these two is called reconstitution, and it's a critical step in proper drug administration

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