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Furthermore, TNF- interferes with the electron transport chain (ETC), resulting in mtDNA degradation and upregulation of hypoxia-inducible factor-1 alpha (HIF-1), both of which exacerbate hepatic hypoxia and oxidative stress [35, 36]

Wolffenbuttel BHR, Wouters HJCM, Heiner-Fokkema MR, van der Klauw MM