Semaglutide mimics a naturally occurring hormone that aids in appetite and blood sugar control
A CMR cine stack in the short-axis plane were acquired to evaluate left ventricle (LV) systolic and diastolic function and a similar LGE stack to evaluate myocardial scarring and replacement fibrosis
The pharmacogenomic architecture is beginning to be characterized
Recommended monitoring includes: Complete blood count, comprehensive metabolic panel Vitamin B12, folate, iron studies, vitamin D, calcium, parathyroid hormone Thiamine in patients with persistent vomiting Protein intake assessment and albumin/prealbumin levels Contraindications include personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, as GLP-1 receptor agonists carry a boxed warning based on rodent studies showing thyroid C-cell tumors
Interestingly, both diarrhoea and constipation were reported, reflecting the variable nature of GI responses seen across this class of drug
Peptides are long chains of amino acids, and they can be physically fragile
