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(2012) Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells, Autophagy , 8 , 1769-1781, doi: Du, J., Wang, T., Li, Y., Zhou, Y., Wang, X., Yu, X., Ren, X., An, Y., Wu, Y., Sun, W., Fan, W., Zhu, Q., Wang, Y., and Tong, X

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Mao found that treating cancer cells with GPX4 inhibitors resulted in acute depletion of N-carbamyl-L-aspartate (C-ASP, a pyrimidine biosynthesis intermediate), accompanied by accumulation of uridine, which could be inhibited by fer-1, a ferroptosis inhibitor [18]

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The dosing itself does not change, but the monitoring requirements are more stringent