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Since most patients on CONTRAVE lost weight in the first 12 weeks, your doctor will check on your weight-loss on the medication at 12 weeks and possibly prior to this time to determine if CONTRAVE is effective for you and should be continued

(70) demonstrated that treatment with GIPRA led to dose-dependent reductions in body weight in both wild-type and GLP-1R knockout mice, and this effect was negated by co-administration of a GIPR antagonist

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