GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda) follow gradual dose-escalation protocols to minimize side effects while achieving therapeutic goals
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MC4R agonism reduces ghrelin signalling and delays the gastric emptying rate, creating early satiety that lasts 48 hours
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There is also a concern regarding side effects, with gastrointestinal issues such as nausea and vomiting being common, which can affect patient adherence