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Xanthine oxidoreductase in atherosclerosis pathogenesis: not only oxidative stress

Studies with animal models of other designations and/or with induced diseases or clinical conditions of any nature will be excluded, and so will be non-experimental models (wild or pet animals), pregnant, weaned, and pubescent animal models

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Initially, such responses can alleviate injury, but long-term overactivation can turn them harmful, thereby leading to compensatory reactions, namely, antagonistic characteristics of aging

The specific activities of the enzymes involved in GSH, Cys and Met metabolism will be determined along with the levels of specific intermediate metabolites in different tissues

Supplements should mimic that, not flood the system